ABSTRACT
Objective To investigate the clinical effect of cefoxitin sodium combined with Kangfuyan capsules in the treatment of pelvic inflammatory disease and its influence on inflammatory cytokines .Methods According to the random number table method ,450 cases with chronic pelvic inflammatory disease were divided into the observation group and the control group ,225 cases in each group .The observation group was given cefoxitin sodium combined with Kangfuyan capsules treatment ,the control group received cefoxitin sodium therapy .The treatment effect and the changes of inflammatory cytokines before and after treatment were compared between the two groups .Results The total effective rate(93.3％vs.86.7％) and the cure rate(66.7％vs.53.5％) of the observation group were signif-icantly higher than those of the control group ,the differences were statistically significant (χ2 =8.333,5.556,all P<0.05).After treatment,the TNF-alpha,IL-6 and CRP levels in the two groups were significantly decreased ,which of the observation group were better than those of the control group [(43.7 ±18.2)ng/L vs.(53.2 ±21.6)ng/L, (323.8 ±124.6)ng/L vs.(399.5 ±141.3)ng/L,(9.7 ±3.5)mg/L vs.(13.4 ±5.9)mg/L],the differences were statistically significant(t=7.865,5.783,4.517,all P<0.05).Conclusion Cefoxitin sodium combined with Kang-fuyan capsule in the treatment of chronic pelvic inflammatory disease ,can significantly improve the treatment effect , improve the level of inflammatory cytokines .